Pharmacokinetics-On-a-Chip: In Vitro Microphysiological Models for Emulating of Drugs ADME

Introduction Drug compounds' effectiveness, toxicity, and pharmacokinetics may be more accurately predicted in humans with the use of Organ-on-a-Chip technology.…

4 years ago

Liver microphysiological platforms for drug metabolism applications

Introduction Liver microphysiological platforms for drug metabolism applications are the need of the hour to fix the exorbitant costs of…

4 years ago

Adipose Tissue-Endothelial Cell Interactions in Obesity-Induced Endothelial Dysfunction

Introduction Adipose tissue progenitor cells directly interact with endothelial cells to induce vascular network formation. Adipose Tissue regulates the production…

4 years ago

A versatile microfluidic tool for the 3D culture of HepaRG cells seeded at various stages of differentiation

Introduction Recently, microfluidics and 3D cell culture technologies have merged, to increase the potential of in vitro modeling, in order…

4 years ago

Adipocyte heterogeneity underlying adipose tissue functions

Introduction Adipose tissue does not only store energy, it also governs the metabolism of cells and tissues around the body…

4 years ago

A new microfluidic method enabling the generation of multi-layered tissues-on-chips using skin cells as a proof of concept (Valencia et al, 2021)

Introduction Every organ is composed of a mesenchymal (stroma) and a parenchymal fraction. Conventional two-dimensional (2D) cultures are often focusing…

4 years ago

Restorative effect of adipose tissue-derived stem cells on impaired hepatocytes through Notch signaling in non-alcoholic steatohepatitis mice (Ishida et al, 2021)

Introduction Adipose tissue-derived stem cells (ADSCs) are mesenchymal stem cells (MSCs) that are obtained from abundant adipose tissue, adherent on…

4 years ago

Perilipin 5 links mitochondrial uncoupled respiration in brown fat to healthy white fat remodeling and systemic glucose tolerance (Gallardo-Montejano et al, 2021)

Introduction - According to a recent study headed by UT Southwestern researchers, increasing a protein contained in brown fat appears…

4 years ago

Rebuilding the Vascular Network: In vivo and in vitro Approaches (Meng et al, 2021)

Introduction The vascular network carries the transportation of materials and nutrients as the fluid delivery mechanism of the human body.…

4 years ago

Experimental liver models: from cell culture techniques to microfluidic organs-on-chip (Polidoro et al, 2021)

Introduction - The Organ-on-a-Chip (OOAC) is a leading organ biomimetic (POB) device based on a microfluidic chip in the list…

4 years ago

Observation Internship (Stage d’observation) at Cherry Biotech – Lukas Marcel

Last week we had the pleasure of receiving Lukas Marcel as an intern at Cherry Biotech for one week. This…

4 years ago