Multiorgan Microphysiological Systems as Tools to Interrogate Interorgan Crosstalk and Complex Diseases

3 years ago
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Introduction MPS (Multiorgan Microphysiological Systems) have evolved from tools to reduce animal experimentation and improve preclinical toxicity assessments to an…

Microfluidic organ-on-chip system for multi-analyte monitoring of metabolites in 3D cell cultures

Introduction The researchers created a microfluidic organ-on-chip solution with integrated electrochemical microsensor arrays enabling compartmentalized matrix-based organoid culture from single…

3 years ago

A new microfluidic method enabling the generation of multi-layered tissues-on-chips using skin cells as a proof of concept

Introduction The state of the art for tissues-on-chips using skin cells had been lacking for a long time due to…

3 years ago

Pumpless, modular, microphysiological systems enabling tunable perfusion for long-term cultivation of endothelialized lumens

Introduction The authors present a simple and modular Microphysiological system without the use of complex components consisting of 1) a…

4 years ago

Facilitating implementation of organs-on-chips by open platform technology

Introduction Many Organ-on-Chip platforms are still not robust for all cell types, are not reproducible from experiment to experiment or…

4 years ago

Skin on a chip state of the art

Why a skin on a chip? The skin is the outer envelope of the body. It contains pressure, temperature, and pain…

4 years ago

Low-cost rapid prototyping and assembly of an open microfluidic device for a 3D vascularized organ-on-a-chip

Introduction In vitro generation of perfusable 3D microvessels is an important goal for tissue engineering and reliable modeling of blood…

4 years ago

Co-culture With Human Breast Adipocytes Differentially Regulates Protein Abundance in Breast Cancer Cells

Introduction In postmenopausal women, fat mass and adipose-tissue mass (see Human Breast Adipocytes) are closely linked to obesity and breast…

4 years ago