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Multiorgan Microphysiological Systems as Tools to Interrogate Interorgan Crosstalk and Complex Diseases

Introduction MPS (Multiorgan Microphysiological Systems) have evolved from tools to reduce animal experimentation and improve preclinical toxicity assessments to an…

3 years ago

Microfluidic organ-on-chip system for multi-analyte monitoring of metabolites in 3D cell cultures

Introduction The researchers created a microfluidic organ-on-chip solution with integrated electrochemical microsensor arrays enabling compartmentalized matrix-based organoid culture from single…

3 years ago

A new microfluidic method enabling the generation of multi-layered tissues-on-chips using skin cells as a proof of concept

Introduction The state of the art for tissues-on-chips using skin cells had been lacking for a long time due to…

4 years ago

Pumpless, modular, microphysiological systems enabling tunable perfusion for long-term cultivation of endothelialized lumens

Introduction The authors present a simple and modular Microphysiological system without the use of complex components consisting of 1) a…

4 years ago

Facilitating implementation of organs-on-chips by open platform technology

Introduction Many Organ-on-Chip platforms are still not robust for all cell types, are not reproducible from experiment to experiment or…

4 years ago

Skin on a chip state of the art

Why a skin on a chip? The skin is the outer envelope of the body. It contains pressure, temperature, and pain…

4 years ago

Low-cost rapid prototyping and assembly of an open microfluidic device for a 3D vascularized organ-on-a-chip

Introduction In vitro generation of perfusable 3D microvessels is an important goal for tissue engineering and reliable modeling of blood…

4 years ago

Co-culture With Human Breast Adipocytes Differentially Regulates Protein Abundance in Breast Cancer Cells

Introduction In postmenopausal women, fat mass and adipose-tissue mass (see Human Breast Adipocytes) are closely linked to obesity and breast…

4 years ago