Organs-on-a-chip

Pharmacokinetics-On-a-Chip: In Vitro Microphysiological Models for Emulating of Drugs ADME

Introduction Drug compounds' effectiveness, toxicity, and pharmacokinetics may be more accurately predicted in humans with the use of Organ-on-a-Chip technology.…

4 years ago

Liver microphysiological platforms for drug metabolism applications

Introduction Liver microphysiological platforms for drug metabolism applications are the need of the hour to fix the exorbitant costs of…

4 years ago

A versatile microfluidic tool for the 3D culture of HepaRG cells seeded at various stages of differentiation

Introduction Recently, microfluidics and 3D cell culture technologies have merged, to increase the potential of in vitro modeling, in order…

4 years ago

A new microfluidic method enabling the generation of multi-layered tissues-on-chips using skin cells as a proof of concept (Valencia et al, 2021)

Introduction Every organ is composed of a mesenchymal (stroma) and a parenchymal fraction. Conventional two-dimensional (2D) cultures are often focusing…

4 years ago

Rebuilding the Vascular Network: In vivo and in vitro Approaches (Meng et al, 2021)

Introduction The vascular network carries the transportation of materials and nutrients as the fluid delivery mechanism of the human body.…

4 years ago

Experimental liver models: from cell culture techniques to microfluidic organs-on-chip (Polidoro et al, 2021)

Introduction - The Organ-on-a-Chip (OOAC) is a leading organ biomimetic (POB) device based on a microfluidic chip in the list…

4 years ago

Review on the Vascularization of Organoids and Organoids-on-a-Chip (Xingli and Zilu et al, 2021)

Introduction Organoids and organs-on-a-chip (vascularized 3d culture) have seen rapid growth in recent years due to their importance in mimicking…

4 years ago

OOCHIP: Compartmentalized Microfluidic Perfusion System with Porous Barriers for Enhanced Cell-Cell Crosstalk in Organ-on-a-Chip (Ramadan et al)

Abstract: (Ramadan et al) : Improved in vitro models of human organs for predicting drug efficacy, interactions, and disease modeling…

4 years ago

Introduction to the human body

The human body: systems, organs, and main functions The human body is composed of several different subsystems ranging from microscopic…

4 years ago

Human Microbiota and Microbioma : in vitro Culturing Approaches

The Human Microbiota present in the body Trillions of microorganisms habit the human body. Bacteria, fungi, viruses and archaea that…

5 years ago

Skeletal Muscle Biopsy Beyond Histological Diagnosis: Ex-vivo Culturing and 3D Bioengineered model

Skeletal Muscle: Overview, Histology, and Pathology Muscle tissue represents one of the four tissue in the human body with the…

5 years ago

Intestinal Biopsies Beyond Histological Diagnosis: Ex-vivo Culturing and Precision Cut Slices for Precision Pharmacology

Intestine: Overview, Histology and Pathology  The intestine is the largest part of the alimentary canal, which is part of the…

5 years ago