Introduction Microfluidic 3D Endothelium-on-a-Chip - The endothelium is a thin membrane that lines the heart and blood vessels. Endothelial cells secrete chemicals that regulate vascular relaxation and contraction, as well…
3D Microphysiological System Vascularized Tissue - Human vascular microphysiological systems (MPS) represent promising three-dimensional in vitro models of normal and diseased vascular tissue. These systems, which mimic essential functional components…
Introduction Organ-on-a-Chip is a potential, multidisciplinary method for in-vitro modeling of disease, drug screening, and precision medicine that simulates in-vitro physiology and pathology. Organ-on-a-Chip: A New Paradigm for Drug Development?Organ-on-a-chip…
Introduction The extracellular matrix (ECM) is the non-cellular component present within all tissues and organs, which provides not only important physical support in cellular elements but also initiates key biochemicals…
Introduction As a novel technology for in vitro toxicity testing platforms in recent years, Microphysiological Systems (MPS) have been actively developed. MPS are cultural techniques for the rebuilding of human…
Introduction Organ-on-a-chip is regarded as a key new technology for research and development because it can predict how a potential medication will behave in human tissue structures – rather than…
Introduction PDMS, often known as dimethylpolysiloxane or dimethicone, is a silicone polymer. There are various uses for PDMS owing to its flexibility and characteristics. Although PDMS is a very good…
Introduction Drug compounds' effectiveness, toxicity, and pharmacokinetics may be more accurately predicted in humans with the use of Organ-on-a-Chip technology. Pharmacokinetics-On-a-Chip: In Vitro Microphysiological Models are the future of emulating…
Introduction Recently, microfluidics and 3D cell culture technologies have merged, to increase the potential of in vitro modeling, in order to get even closer to human physiology. Control of the…
Introduction Every organ is composed of a mesenchymal (stroma) and a parenchymal fraction. Conventional two-dimensional (2D) cultures are often focusing on the mimicking of the parenchymal fraction (eg, hepatocytes, enterocytes,…
Introduction - The Organ-on-a-Chip (OOAC) is a leading organ biomimetic (POB) device based on a microfluidic chip in the list of the top ten innovative technologies. The microenvironment of the…