Cubix Microphysiological system

CubiX

The first incubator-free microphysiological system in the world. It enables mimicking physiological and pathological culture conditions in vitro. CubiX is the only microenvironment controller fully compatible with live imaging. You will never be blind to your sample ever.

CubiX is scalable & customizable allowing you to use custom made chips, multiwell, commercial microfluidic chip, and many more to help you get better and longer biological culture.

Get a quote or technical information

Cherrybiotech

Main Features

PDMS free

The only commercial MPS PDMS free device with no bias in toxicology and efficacy studies

Incubator free

Direct integration in existing analysis workflow, without disruption of the culture conditions

Compatible with culture standard

From 6 to 24 well allowing a direct transfer of the culture protocol

Vascularized 3D biological model

Physiological maintenance of a differentiated endothelium with an organ stroma >5 days

Overview

As deep tech entrepreneurs, we choose the entrepreneurial path instead of the academic one. We are a team of risk-takers and we need to do more with less.

We are now at an early stage of development of our company before the product-market fit. Cubix, our main product, is in a pre-sales phase.

  • Cubix Control Unit
  • Integrated Software
  • Created by shashank singhfrom the Noun Project Culture Medium Collection Flasks
  • Created by Vectors Pointfrom the Noun Project External Culture Medium Reservoir
  • Cubix Culture Unit
Cubix Control Unit

Emulating human cells and tissues physiology (Renewal/Shear stress)

Integrated Software

User-friendly interface to pilot Cubix control unit, no need for external devices to control

Culture Medium collection flask

Allows to collect culture medium at the exit of the culture unit for further analysis.

Created by Vectors Pointfrom the Noun Project
External Culture medium reservoir

For long-term experiments, up to 4 different medium compositions.

71 - Electric Heater (Solid)Created with Sketch.Created by Ben Davisfrom the Noun Project
Cubix culture unit

The versatile element of Cubix can be used from 6 to 24 well plates, as well as any commercial microfluidic chip.

Technical Specifications

We developed the first Plug & Play system that take advantages both of organ-on-a-chip technologies and artificial intelligence analysis. CubiX allows performing all your in-vitro experiments in a controlled microenvironment with the automated acquisition of optical, biochemical and electrophysiological parameters.

Artificial intelligence will take advantage of resulting massive data in order to assist users in taking decisions and better interpreting results.

Temprature Control

RANGE - 0 - 80° C
ACCURACY- MAX 0.5° C REGULAR 0.25° C
Stable over weeks

Medium Perfusion

Continuous Flow - 70μL/min to 20mL/min
Pulsative Flow - Max 8μL/min to 20ml/min
Mimic any shear stress in the human body

Gas Control

CO2 N2 O2
Upon request: H2, NO2, and others...
Tunability 0-100%
HYPOXIA NORMOXIA HYPEROXIA

Chambers/Culture units

Special Culture Device - 24 multi well plate, 6 well plate + Transwell membrane
Commercially available by - CherryBiotech, Ibidi. Beon-chip. Chamber
Chips developed by customers

User Interface

Testimonials

Learn how Cubix impacted researchers, the first incubator-free microenvironment controller in the world. Enabled the mimicking of physiological and pathological culture conditions in vitro. CubiX is the only microenvironment controller fully compatible with live imaging. You will never be blind to your sample ever.

CubiX is scalable & customizable allowing you to use custom made chips, multiwell, commercial microfluidic chip, and many more to help you get better and longer biological culture.

Cubix and its consumables compatible with multi-well plates are versatile and do not upset the operative praxis of biomedical researchers. Further, the consumable can be configurated with a high customizable interconnection layout of the wells ensuring desired intra- and inter-well gradients.
Matteo BONINSEGNA
PHD STUDENT / H2020-ITN-DELIVER
Cubix! This cube fixes everything that I wished for. Cubix empowered us in replicating effortlessly the microenvironment conditions for spermatozoa swimming. Customized physiological gases enrichment with high degree control of flow and temperature allowed us to develop a repeatable, user-friendly, and automated biological protocol
Shiva K SHUKLA, PhD
Post-doc Marie Curie Individual Fellowship, project MicroFSMA
An easy to grasp user interface and near-complete plug-n-play assembly allows for using low-to-medium throughput consumables. Customizable liquid flow patterns allow for easy micro-tissue and multi-organ zonation designs.
François TAUTE, PhD
Post-doc Marie Curie Individual Fellowship, project Mimetic Indirect
I thoroughly enjoyed working with CubiX, and particularly appreciated that I could control the dissolved oxygen in the culture unit. This I then could also monitor through the systems compatibility with in-line sensors.
Miriam GRAUTE, PhD
PHD STUDENT / H2020-ITN EID-GROWTH

Discover the applications of Cubix

Applications

Diabetes Knowlegde Centre

Type 2 Diabetes Mellitus: Evaluating the Safety of New Drugs for Improving Glycemic Control Guidance for Industry
The International Diabetes Federation (IDF) is an umbrella organization of over 230 national diabetes associations in 170 countries and territories. It represents the interests of the growing number of people with diabetes and those at risk
Understanding medicine -Type 2 diabetes
World Health Organization Diabetes Fact Sheet
With diabetes, knowledge is power. Explore this collection of articles created for people with diabetes or who are at risk for diabetes, and their families and friends.
The European Medicines Agency (EMA) is a decentralised agency of the European Union (EU). It began operating in 1995. The Agency is responsible for the scientific evaluation, supervision and safety monitoring of medicines in the EU.