The Liver: Overview, Histology and Pathology The liver (Fig. 1) is the largest organ in the human body and responsible for 1stand 2ndpass metabolism, where it is the nexus for…
AIMS LIVER BIOPSY ON CHIPLiver Biopsy → Increase biopsies viability in long term culture liver biopsy → Imaging and biochemical quantification of drug effect → Interface blood vessel/hepatocyte → DILI assessment based on…
Organs-on-Chip for Drug DevelopmentA drug should pass the preclinical evaluation phase to be FDA-approved. This relies (i) on in vitro cell culture platforms and (ii) on in vivo animal models…
The liver is a fundamental organ for human life. It is responsible for macromolecules (carbohydrates, fats, protein) metabolization and the detoxification of our blood as well. The liver structure is…
Why a muscle on a chip? FUN FACT: Skeletal muscles account for 40% of the total body weight in humans and consume about 30% of energy intake. Skeletal muscles are…
Why a pancreas on a chip? The pancreas is an annex gland of the digestive system. It has both endocrine and exocrine functionality. Its exocrine function consists of the secretion…
Why a heart on a chip? The heart is the central element of the cardiovascular system. If it is dysfunctional, other organs will not receive enough oxygen. Some pharmaceuticals induced…
Why a liver on a chip? The liver is part of the digestive tract, and the main organ involved in the metabolism of xenobiotics, thus in toxicological studies (either fundamental…
Introduction to 3D Liver Cell Culture Once it is clear how to deal with 3D cell cultures it is time to focus on one type of cell and analyze its…
Why and how? From 2D to 3D cell culture: The main issues find while using 2D cell systems, is that it is not possible to have access to the specific architecture…
Spheroids: What are they and what are their uses? In an organ, a cell needs to be considered together with its whole environment. Each cell is surrounded by a myriad…
What is the organotypic culture? Organotypic culture is defined as the culture of an organ collected from an organism. It is one method allowing the culture of complex tissues or…