Introduction Drug compounds' effectiveness, toxicity, and pharmacokinetics may be more accurately predicted in humans with the use of Organ-on-a-Chip technology. Pharmacokinetics-On-a-Chip: In Vitro Microphysiological Models are the future of emulating…
Introduction Liver microphysiological platforms for drug metabolism applications are the need of the hour to fix the exorbitant costs of drug development. Toxicology or lack of efficacy are two of…
Introduction Recently, microfluidics and 3D cell culture technologies have merged, to increase the potential of in vitro modeling, in order to get even closer to human physiology. Control of the…
Introduction Every organ is composed of a mesenchymal (stroma) and a parenchymal fraction. Conventional two-dimensional (2D) cultures are often focusing on the mimicking of the parenchymal fraction (eg, hepatocytes, enterocytes,…
Introduction The vascular network carries the transportation of materials and nutrients as the fluid delivery mechanism of the human body. Tissue engineering research, therefore, focuses primarily on the forming of…
Introduction - The Organ-on-a-Chip (OOAC) is a leading organ biomimetic (POB) device based on a microfluidic chip in the list of the top ten innovative technologies. The microenvironment of the…
Introduction Organoids and organs-on-a-chip (vascularized 3d culture) have seen rapid growth in recent years due to their importance in mimicking the shape and operation of human organs. At the moment,…
Abstract: (Ramadan et al) : Improved in vitro models of human organs for predicting drug efficacy, interactions, and disease modeling are crucially needed to minimize the use of animal models,…
The human body: systems, organs, and main functions The human body is composed of several different subsystems ranging from microscopic scales to macroscopic levels. All the functions are controlled by…
The Human Microbiota present in the body Trillions of microorganisms habit the human body. Bacteria, fungi, viruses and archaea that are part of the human microbiota colonize the skin, the…
Skeletal Muscle: Overview, Histology, and Pathology Muscle tissue represents one of the four tissue in the human body with the epithelial tissue, connective tissue, and nervous tissue. Embryologically, the muscle…
Intestine: Overview, Histology and Pathology The intestine is the largest part of the alimentary canal, which is part of the gastrointestinal tract (also called ‘gut’) that, with accessory glands, form…