Introduction MPS (Multiorgan Microphysiological Systems) have evolved from tools to reduce animal experimentation and improve preclinical toxicity assessments to an intriguing stepping stone in efforts to replicate our own biology.…
Introduction Melanoma is clearly a complex disease with a high degree of heterogeneity and adaptability. Melanoma cells are part of a larger ecosystem in which the tumor microenvironment influences their…
Introduction The researchers created a microfluidic organ-on-chip solution with integrated electrochemical microsensor arrays enabling compartmentalized matrix-based organoid culture from single stem cells and real-time recording of metabolic data. These patient-derived…
Introduction Animal models and two-dimensional (2D) cell cultures frequently fail to replicate human drug metabolism and liver toxicity in vivo, therefore there is a need for 3D Culture of HepaRG…
Introduction Adipose Tissue is very versatile and essential for studies related to Obesity and Diabetes, however, the high buoyancy, fragility, and heterogeneity of primary adipocytes have largely prevented their use…
Introduction The authors present a simple and modular Microphysiological system without the use of complex components consisting of 1) a resistance module that controls the flow rate and 2) a…
Introduction Many Organ-on-Chip platforms are still not robust for all cell types, are not reproducible from experiment to experiment or user to user, and should be independently qualified as fit…
Why a skin on a chip? The skin is the outer envelope of the body. It contains pressure, temperature, and pain sensors and synthesizes vitamin D through sunlight. It is a…
Introduction The gut-liver axis is the bidirectional interaction that exists between the gut and its microbiota, as well as the liver, and is the outcome of the integration of signals…
Introduction In vitro generation of perfusable 3D microvessels is an important goal for tissue engineering and reliable modeling of blood vessel function. In vitro blood vessel models have yet to…
Introduction In postmenopausal women, fat mass and adipose-tissue mass (see Human Breast Adipocytes) are closely linked to obesity and breast cancer. Adipocytes have the ability to modulate the tumor microenvironment…
Introduction Organ-on-Chips for Studying Tissue Barriers - Disruption of cell-formed tissue barriers is an essential part of many diseases' pathophysiology. Therefore, a thorough understanding of tissue barrier function is essential…