A new microfluidic method enabling the generation of multi-layered tissues-on-chips using skin cells as a proof of concept (Valencia et al, 2021)

Introduction Every organ is composed of a mesenchymal (stroma) and a parenchymal fraction. Conventional two-dimensional (2D) cultures are often focusing on the mimicking of the parenchymal fraction (eg, hepatocytes, enterocytes,…

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Tumor microenvironment (TME)

The tumor microenvironment (TME) is a complex biochemical network that includes multiple factors surrounding tumor cells, such as vascular networks, the extracellular matrix (ECM), and a heterogeneous cell population composed…

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Perfusion systems: continuous medium flow for cell culture

Perfusion systemsLong-term imaging of cultured cells requires controlled environmental conditions. Continuous perfusion of the medium allows maintaining cells under optimal physiological conditions, with constant nutrient supply and controlled pH environment…

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