Introduction Animal models and two-dimensional (2D) cell cultures frequently fail to replicate human drug metabolism and liver toxicity in vivo, therefore there is a need for 3D Culture of HepaRG…
Introduction Liver microphysiological platforms for drug metabolism applications are the need of the hour to fix the exorbitant costs of drug development. Toxicology or lack of efficacy are two of…
Introduction Adipose tissue-derived stem cells (ADSCs) are mesenchymal stem cells (MSCs) that are obtained from abundant adipose tissue, adherent on plastic culture flasks can be expanded in vitro, and have the…
Introduction - The Organ-on-a-Chip (OOAC) is a leading organ biomimetic (POB) device based on a microfluidic chip in the list of the top ten innovative technologies. The microenvironment of the…
AIMS LIVER BIOPSY ON CHIPLiver Biopsy → Increase biopsies viability in long term culture liver biopsy → Imaging and biochemical quantification of drug effect → Interface blood vessel/hepatocyte → DILI assessment based on…
The liver is a fundamental organ for human life. It is responsible for macromolecules (carbohydrates, fats, protein) metabolization and the detoxification of our blood as well. The liver structure is…