Adipose tissue progenitor cells directly interact with endothelial cells to induce vascular network formation. Adipose Tissue regulates the production of hormones, angiogenic factors, and cytokines. During the development of obesity, Adipose Tissue expands through the increase in fat cell size (hypertrophy) and/or fat cell number (hyperplasia). Adipose Tissue Endothelial Cell Interactions are necessary to study Obesity-Induced Endothelial Dysfunction.
The plasticity and expansion of Adipose Tissue are related to its angiogenic capacities. Angiogenesis is a tightly orchestrated process, which involves endothelial cell (EC) proliferation, migration, invasion, and new tube formation. The expansion of Adipose Tissue is accelerated by hypoxia, inflammation, and structural remodeling of blood vessels. The paracrine signaling regulates the functional link between Endothelial Cells and Adipocytes.
The paper below tells us about how obesity induces endothelial dysfunction, which often precedes and leads to the development of cardiovascular diseases. Adipose-to-endothelial cell interaction may help us comprehend obesity-induced cardiovascular disease more effectively.
Adipose Tissue-Endothelial Cell Interactions in Obesity-Induced Endothelial Dysfunction
The authors state that “Obesity has a strong impact on the pathogenesis of the cardiovascular disease, which raises enthusiasm to understand how excess adiposity causes vascular injury. Adipose tissue is an essential regulator of the cardiovascular system through its endocrine and paracrine bioactive products.
Obesity induces endothelial dysfunction, which often precedes and leads to the development of cardiovascular diseases. Connecting adipose tissue-endothelial cell interplay to endothelial dysfunction may help us to better understand obesity-induced cardiovascular disease.
This Mini-Review discussed (1) the general interactions and obesity-induced endothelial dysfunction, (2) potential targets, and (3) the outstanding questions for future research.”
Li M, Qian M, Kyler K, Xu J. Adipose Tissue-Endothelial Cell Interactions in Obesity-Induced Endothelial Dysfunction. Front Cardiovasc Med. 2021 Jul 1;8:681581. DOI: 10.3389/fcvm.2021.681581. PMID: 34277732; PMCID: PMC8282205.